Strain Isolation & Characterisation
More than 1,000 isolates from diverse sources enter phenotypic screening and strain-level analysis, including 16S rRNA and whole-genome sequencing.
NBC Probiotics®
Product Type
Probiotic Cultures
Portfolio
21 Registered Strains
Form
Powder
Key Feature
A versatile probiotic portfolio developed for different formulation requirements.
From discovery to stable cultures
NBC Probiotics follows a traceable pathway from microbial isolation and strain-level identification to safety screening, scalable production and stabilisation.
Launched in 2018, the programme now includes 21 strains registered with international culture collections.
Research to production
The Nuvita Biosearch Center, approved as an R&D Centre by Türkiye’s Ministry of Industry and Technology in 2021, combines microbiology, cell culture, fermentation and bioprocess capabilities.
Strain identification, probiotic and safety assessment, and production are linked in one development process for stable, high-concentration cultures.
From strain discovery to stable culture
A single, traceable development pathway connects isolation, strain-level identification, functional and safety screening, controlled scale-up and stabilisation.
DiscoverDiverse microbial sources and a culture collection of more than 1,000 isolates.
CharacterisePhenotypic analysis, 16S rRNA sequencing and whole-genome sequencing.
ValidateGastrointestinal tolerance, cell interaction, microbial activity and safety screening.
Scale & stabiliseControlled fermentation, high-cell-density production and freeze-drying know-how.
Probiotic Properties & Safety
Candidate strains are assessed for gastrointestinal tolerance, cell interaction, microbial activity and safety indicators before selection.
Production Technology & Scalability
Strain-specific media and fermentation conditions are refined in controlled bioreactors to support reproducible, high-concentration production.
Stabilisation & High-Concentration Production
Cryoprotectant systems and freeze-drying parameters are evaluated to help preserve culture viability through processing and storage.
Strain Portfolio
21 strains registered with international culture collections.
| Species / Subspecies | Strain Code | DSMZ Code | |
| 1 | Bifidobacterium longum | NBC2255 | DSM 35104 |
| 2 | Bifidobacterium longum | NBC3191 | DSM 35235 |
| 3 | Lacticaseibacillus casei | CK9193 | DSM 34906 |
| 4 | Lacticaseibacillus casei | MMA1997 | DSM 35240 |
| 5 | Lacticaseibacillus paracasei | CC8169 | DSM 35237 |
| 6 | Lacticaseibacillus paracasei | YEA81 | DSM 34908 |
| 7 | Lacticaseibacillus rhamnosus | NSA4949 | DSM 35238 |
| 8 | Lacticaseibacillus rhamnosus | SA74 | DSM 35032 |
| 9 | Lactiplantibacillus plantarum | NBC622 | DSM 35241 |
| 10 | Lactiplantibacillus plantarum | NBC99 | DSM 34913 |
| 11 | Lactobacillus delbrueckii subsp. bulgaricus | HU8278 | DSM 35029 |
| 12 | Lactobacillus helveticus | NBC2435 | DSM 35031 |
| 13 | Lactobacillus helveticus | NBC5923 | DSM 35234 |
| 14 | Levilactobacillus brevis | AI7964 | DSM 35239 |
| 15 | Levilactobacillus brevis | TT8577 | DSM 34907 |
| 16 | Limosilactobacillus fermentum | NBC114 | DSM 34935 |
| 17 | Limosilactobacillus fermentum | NBC3682 | DSM 35242 |
| 18 | Limosilactobacillus pontis | ZZ6780 | DSM 35030 |
| 19 | Limosilactobacillus reuteri | NBC113 | DSM 35236 |
| 20 | Limosilactobacillus reuteri | NBC2680 | DSM 34936 |
| 21 | Streptococcus thermophilus | NBC5527 | DSM 34914 |
Scientific Outputs
Peer-reviewed publications and scientific congress presentations.
- Characterization of Nuvita Biosearch Center (NBC) Isolated Lactic Acid Bacteria Strains from Human Origin and Determination of Growth Kinetic Profiles of Selected Cultures under Bioreactor. Kavak, A. E., Zent, İ., Sağır, E. M., Öncü, G., & Şimşek, F. İ. (2024). Annals of Microbiology, 74, 26. DOI: 10.1186/s13213-024-01772-9
- Isolation and Characterization of Probiotic Lactic Acid Bacteria from Traditional Turkish Fermented Foods with in Vitro Safety and Functional Evaluation. Kavak, A. E., Kan, N., Orsel, E. K., Cağlayan, İ. N., & Alimoğlu, Z. B. (2026). Current Nutrition & Food Science, 22, Early View. DOI: 10.2174/0115734013436827260306061228
- Optimization of Cryoprotectant Formulation to Enhance the Viability of Lactiplantibacillus plantarum NBC99 Isolated from Human Origin. Kavak, A. E., Zent, İ., Özdemir, A., & Dertli, E. (2024). Preparative Biochemistry & Biotechnology, 54(7), 958–966. DOI: 10.1080/10826068.2024.2312450
- Optimization of Media Composition for Maximum Growth of Probiotic Lactobacillus fermentum NBC-08 Using Response Surface Methodology. Kavak, A. E., Selen, V., & Tamtürk, F. (2022). Yuzuncu Yıl University Journal of Agricultural Sciences, 32(1), 69–80. DOI: 10.29133/yyutbd.993781
- Paediatricians’ Perspectives on Probiotics. Şahin, V., Karbuz, A., Öksüzoğlu, E., Tezer, H., Özdemir, F., Kavak, A. E., Beşel, L., Turan, M., & Kara, A. (2025). 18th National Paediatric Infectious Diseases Congress.
- Determination of Probiotic Properties of Streptococcus thermophilus NBC5527 Strain Isolated from Traditional Yogurt and Pilot Scale Production. Kavak, A. E., Alimoğlu, Z. B., & Dertli, E. (2025). 2nd Food Microbiology Congress of Türkiye. Oral presentation.
- Gastrointestinal Tolerance of Nuvita Biosearch Center (NBC) Lactic Acid Bacteria Isolated from Different Sources. Kavak, A. E., Gün Sezen, A., Mamay Yıldırım, S., Alimoğlu, S., Tezer, H., & Kara, A. (2024). 4th Eastern Paediatrics Congress. Oral presentation.
- Identification of Nuvita Biosearch Center (NBC) Lactic Acid Bacteria Isolated from Colostrum and Human Milk and Determination of Selected Probiotic Properties. Kavak, A. E., Gün Sezen, A., Çavuş Orhan, Ö., Şimşek, F. İ., Kesgin, S., & Alimoğlu, Z. B. (2024). 68th National Paediatrics Congress. Poster presentation.
- Oral-Use Simulation Studies of Bifidobacterium spp. Isolated at Nuvita Biosearch Center (NBC) and Selection of the Optimal Strain. Kavak, A. E., Gün Sezen, A., Mamay Yıldırım, S., Alimoğlu, S., Tezer, H., & Kara, A. (2024). 4th Eastern Paediatrics Congress. Oral presentation.
- Safety Assessment of Bifidobacterium longum NBC2255 DSM 35104 Isolated from Local Sources at Nuvita Biosearch Center (NBC). Kavak, A. E., Gün Sezen, A., Kan, N., Örsel, E. K., & Alimoğlu, Z. B. (2024). 68th National Paediatrics Congress. Poster presentation.
- Postbiotics Derived from Lactobacillus helveticus NBC2435: Antioxidant and Antibacterial Properties. Kavak, A. E., & Dertli, E. (2025). 4th International Food Chemistry Congress. Poster presentation.
- Potential Probiotic Characterization of NBC-Lacticaseibacillus casei CK9193 and Lactobacillus Strains Isolated from Fermented Turkish Traditional Beverage, Shalgam. Kavak, A. E., Sağır, E. M., & Öncü, G. (2024). Yıldız Technical University International Food Innovation and Sustainability Congress (IFIS Congress 2024). Poster presentation.
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Documents & samples, on request
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